Detailed view for OVOC10137

Basic information

TDR Targets ID: 990627
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 6.9398 | Length (AA): 641 | MW (Da): 72261 | Paralog Number: 3

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01569  

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0003824   catalytic activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
172 217 4zlt (A) 201 260 41.00 0 0.34 0.193997 2.6
193 272 6fmx (A) 111 190 19.00 0.7 0.08 0.459338 -0.04

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130252)

Species Accession Gene Product
Brugia malayi Bm1_18595   PAP2 superfamily protein
Caenorhabditis elegans CELE_F53C3.13   Protein F53C3.13, isoform C
Drosophila melanogaster Dmel_CG8805   wunen-2
Drosophila melanogaster Dmel_CG8804   wunen
Echinococcus granulosus EgrG_000635000   phosphatidate phosphatase
Echinococcus granulosus EgrG_000283300   phosphatidate phosphatase
Entamoeba histolytica EHI_124450   lipid phosphate phosphatase, putative
Echinococcus multilocularis EmuJ_000283300   phosphatidate phosphatase
Echinococcus multilocularis EmuJ_000635000   phosphatidate phosphatase
Homo sapiens ENSG00000162407   phosphatidic acid phosphatase type 2B
Homo sapiens ENSG00000067113   phosphatidic acid phosphatase type 2A
Loa Loa (eye worm) LOAG_08820   hypothetical protein
Loa Loa (eye worm) LOAG_09294   hypothetical protein
Loa Loa (eye worm) LOAG_12928   hypothetical protein
Loa Loa (eye worm) LOAG_09343   hypothetical protein
Mus musculus ENSMUSG00000028517   phosphatidic acid phosphatase type 2B
Mus musculus ENSMUSG00000021759   phosphatidic acid phosphatase type 2A
Neospora caninum NCLIV_063870   hypothetical protein
Onchocerca volvulus OVOC12459   Diacylglycerol pyrophosphate (Phosphatidic acid) phosphatase 1 homolog
Onchocerca volvulus OVOC12462   Diacylglycerol pyrophosphate (Phosphatidic acid) phosphatase 1 homolog
Onchocerca volvulus OVOC10137  
Onchocerca volvulus OVOC9787   Diacylglycerol pyrophosphate (Phosphatidic acid) phosphatase 1 homolog
Schistosoma japonicum Sjp_0029140   Lipid phosphate phosphohydrolase 3, putative
Schistosoma japonicum Sjp_0205010   ko:K01080 phosphatidate phosphatase [EC3.1.3.4], putative
Schistosoma mansoni Smp_085240.1   diacylglycerol pyrophosphate (phosphatidic acid) phosphatase 1
Schistosoma mansoni Smp_085240.2   lipid phosphate phosphatase-related
Schistosoma mansoni Smp_171720   lipid phosphate phosphatase-related
Schmidtea mediterranea mk4.009224.00  
Schmidtea mediterranea mk4.004098.01   Diacylglycerol pyrophosphate
Schmidtea mediterranea mk4.002279.10   Diacylglycerol pyrophosphate
Schmidtea mediterranea mk4.002188.01  
Schmidtea mediterranea mk4.009534.00  
Schmidtea mediterranea mk4.024730.00   Diacylglycerol pyrophosphate
Schmidtea mediterranea mk4.023765.01  
Schmidtea mediterranea mk4.002279.00   Diacylglycerol pyrophosphate
Schmidtea mediterranea mk4.003027.04  
Schmidtea mediterranea mk4.001526.01  
Toxoplasma gondii TGME49_247360   PAP2 superfamily protein

Essentiality

OVOC10137 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_247360 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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